• Users Online: 32
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 8  |  Issue : 4  |  Page : 244-252

Noninvasive quantification of liver fat content by different gradient echo magnetic resonance imaging sequences in patients with nonalcoholic fatty liver disease


1 Research Center for Infectious Diseases of Digestive System, School of Medicine; Department of Medical Physics, Faculty of Medicine; Department of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Radiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Radiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz; Department of Radiology Technology, Behbahan Faculty of Medical Sciences, Behbahan, Iran

Correspondence Address:
Dr. Mozafar Naserpour
Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz; Department of Radiology Technology, Behbahan Faculty of Medical Sciences, Behbahan
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmss.JMSS_32_18

Rights and Permissions

Background: Noninvasive quantification of liver fat by gradient echo (GRE) technique is an interesting issue in quantitative magnetic resonance imaging. In this study, the fat content in patients with nonalcoholic fatty liver disease (NAFLD) was quantified with GRE sequences with different T1 and T2*weighting. Methods: This prospective, cross-sectional study was performed on thirty NAFLD patients. Sixteen GRE sequences with different T1weighting were performed with four echo times. In each sequence, repetition time (TR) or flip angle was changed and other parameters were fixed. Forty-eight fat indexes (FIs) from 16 sequences were calculated based on three methods. To determine the relationship between FIs and histological findings, Pearson's correlation coefficient was used at the level of 1% significance. Results: Mean FIs which obtained from Eq. 3 have the maximum values in comparison to other FIs. The maximum FI was 23.58%, which related to heavily T1weighted sequence obtained with method 3. The minimum FI was −2.49%, which related to the minimal T1weighted obtained with method 2. FIs increase with a flip angle, especially at low flip angles. Increase the TR parameter decrease the FIs gradually. Calculated FIs with methods 1 and 3 stronger correlated with histological findings relative to calculated FIs with method 2. Conclusion: For fat quantification, T1relaxation effects probably more critical than T2*. Flip angle parameter could be a major factor causing the overestimation of liver fat content. Sequences with low flip angle are more suitable for fat quantification with methods 1 and 3. In fat quantification with GRE techniques, it is possible that the third and fourth echoes are unnecessary.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed343    
    Printed24    
    Emailed0    
    PDF Downloaded21    
    Comments [Add]    

Recommend this journal